Reviewing New Protocols or Significant Amendments
- Is the project description, rationale and expected outcomes section brief, in layman’s terms and no more than one page?
- Has the PI clearly explained all abbreviations, technical language or jargon that would make it difficult for non-scientists to understand?
- Does the PI provide adequate justification for the use of animals and the proposed species?
- Are the database searches current and sufficiently rigorous?
- Are the animal numbers justified?
- Does the PI provide adequate information explaining how many animals will be used for each experiment?
- Are the procedures clearly explained?
- If the animals are subjected to multiple use experiments, is this explained?
- If the procedures are painful to the animals, is the pain category appropriate to the level of discomfort?
- Will the appropriate sedatives, analgesics or anesthetics be used?
- How are the animals being monitored, and is a schedule provided?
Experience and Training
- Is the PI experienced in procedures included in the experiments?
- Are others on the protocol experienced in the procedures?
- If so, what are their credentials?
- If not, who will train them?
- If the study includes surgical procedures, are personnel who must complete mandatory training identified?
- If there are any special needs for the animals, have they been addressed?
- Are special skills for individuals attending to the animals addressed?
Method of Euthanasia
- Is the method of euthanasia appropriate?
- Is the proper disposal of animals and/or animal parts described?
- Does the PI describe the type of drugs administered to the animals and procedures to follow for animals that become ill (i.e. treatment or euthanization)?
- Who will determine if an animal is ill, and how will it be treated?